pentobarbital decreases amounts of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Stay away from Except if the coadministration outweighs the doable hazard of ponatinib underexposure; observe for indications of reduced efficacy.
pentobarbital will lessen the level or result of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will decrease the extent or result of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
fentanyl intranasal and pentobarbital both maximize sedation. Stay away from or Use Alternate Drug. Restrict use to individuals for whom different treatment alternatives are insufficient
pentobarbital will decrease the level or impact of losartan by impacting hepatic enzyme CYP2C9/ten metabolism. Minimal/Importance Unknown.
pentobarbital will lower the level or influence of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Use of alternative therapies is strongly suggested when linagliptin should be to be administered by using a CYP3A4 inducer
pentobarbital will decrease the extent or outcome of vincristine liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will reduce the level or result of venetoclax by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will increase the level or influence of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of ivosidenib with robust CYP3A4 inducers lowered ivosidenib plasma concentrations.
pentobarbital improves toxicity of buprenorphine, extensive-performing injection by pharmacodynamic synergism. Modify Therapy/Watch Carefully. Coadministration of buprenorphine and benzodiazepines or other CNS depressants will increase threat of adverse reactions which include overdose, respiratory depression, and death. Cessation of here benzodiazepines or other CNS depressants is preferred most often.
pentobarbital will reduce the level or outcome of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will reduce the extent or impact of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Strong or reasonable CYP3A inducers may lessen cobimetinib systemic exposure by >80% and reduce its efficacy.